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Evidence of transdermal magnesium absorption

A growing number of trials and studies are showing the superior absorption levels of transdermal magnesium compared to tablet and capsule supplementation.

Absorption research is fundamental to BetterYou as a brand and as such it has seen us work with some of the world’s leading institutions and associations, adding to the wealth of trials available.

Cardiff University

In vitro transdermal delivery of magnesium

Key finding: The skin started absorption with immediate effect

This in-vitro clinical trial carried out by the University of Cardiff proved that elemental magnesium could be delivered to the cells of the body through a transdermal delivery (through the skin). The trial showed that the skin started absorption with immediate effect and the action was accelerated with a short period of massaging the application area after spraying. It also pointed out that certain additional ingredients (such as aloe vera) can block the magnesium absorption if used together while others (menthol or wintergreen) can enhance absorption.

In vitro transdermal delivery of magnesium – Dr Heard and Dr Houston – Cardiff University Pharmacy and Pharmacology Department 2010.

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The Nutrition Practitioner

A pilot study to determine the impact of transdermal magnesium treatment on serum levels and whole body CaMg ratios

Key finding: Magnesium uptake 5 times faster than tablets

In this study both the blood level as well as the cellular magnesium content were determined with the help of a hair analysis before and after a twelve week transdermal application with a 31 percent saturated magnesium chloride solution. Thereby after a twelve week course of treatment an average rise in the cellular magnesium content of 59.5 percent was determined in 89 percent of the test subjects. With oral magnesium intake, comparable results could first be achieved after nine to twenty four months. Furthermore, all patients showed an average improvement of 25.2 percent in the calcium-magnesium ratio during the test period. As a side effect, clear indications of a detoxification of heavy metals was observed in 78 percent of the test subjects.

A pilot study to determine the impact of transdermal magnesium treatment on serum levels and whole body CaMg ratios – Watkins, K & Josling, PD – The Nutrition Practitioner, Spring 2010

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Migraine Action

Key finding: Magnesium reduces severity and frequency of attacks

A 3-month trial undertaken by Migraine Action, involving 68 participants who experienced at least three migraines each month. Each migraine sufferer used BetterYou™ MagnesiumOil Original spray twice daily (10-20 sprays in all), whilst keeping a migraine diary to track progress. Overall, 50% of the subjects experienced a positive effect on their migraines. All of these sufferers experienced a decrease in the overall severity of attacks and three quarters of them experiencing a reduction in the duration of attacks.

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Journal of Integrative Medicine

Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

Key finding: Significant benefit for fibromyalgia sufferers

The renowned Mayo Clinic in Rochester (USA) investigated, whether magnesium applied transdermally in the form of MagnesiumOil works for fibromyalgia. 40 women with the clinically determined diagnosis “Fibromyalgia” took part in the study. With the help of a special fibromyalgia questionnaire, the type and manifestation of the complaints were documented on a scale. The data were recorded at the beginning, after 2 weeks and 4 weeks treatment time. Every participant was asked to spray and massage in 4 spray strokes twice a day on the arms and legs for 4 weeks. 24 participants completed the study. For all participants, all complaints improved significantly.

Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study – Engen D.J, McAllister S.J., Whipple M.O., Cha S.S., Dion L-J., Vincent A., Bauer B.A., Wahner-Roedler D.L. – Journal of Integrative Medicine Editorial Office.

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Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles

Key finding: Hair follicles significantly contribute towards topical magnesium absorption by up to 40%.

This trial looked to assess the absorption of magnesium through the top layer of skin (stratum corneum) and the role of hair follicles in facilitating this absorption. The research showed the top layer of skin is permeable to magnesium chloride, which is significantly aided by hair follicles.

Permeation is increased both with time magnesium chloride is left on the skin, as well as the concentration of the magnesium chloride solution, with increases in absorption seen up to 60 minutes after application.

Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles – Chandrasekaran N.C., Sanchez W.Y., Mohammed Y.H., Grice J.E., Roberts M.S., Barnard R.T. – Magnesium Journal.

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Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans

Key findings: Transdermally applied magnesium cream significantly increased magnesium levels in participants

This pilot study set out to determine whether magnesium in a cream could be absorbed through the skin to increase magnesium status.

25 participants were randomly assigned either a 56mg magnesium cream or placebo cream to use daily for two weeks, with serum and urinary magnesium levels being tested pre and post intervention.

While the placebo groups baseline levels did not differ, those with the magnesium cream saw a clinically relevant increase in both serum and urinary levels of magnesium.

Even though participant applied relatively low levels of magnesium (56mg daily) the magnesium cream showed a significant increase in magnesium levels.

Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans – Kass L., Rosanoff A., Tanner A., Sullivan K., McAuley W., Plesset M. – PLoS ONE

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